Effect of oral administration of honey on Liver function parameters of albino rats treated with Dichlorvos (sniper)

Background and aim: Dichlorvos, also known as DDVP (2,2-dichlorovinyl dimethyl phosphate) is an organophosphate insecticide cum pesticide. This study is to determine the effect of oral administration of honey on Liver function parameters of albino rats treated with Dichlorvos (sniper). Experimental procedure: Twenty five albino rats divided into 5groups of 5 rats were administered with 15mg/kg dichlorvos, 15mg/kg dichlorvos and 1ml honey, 15mg/kg dichlorvos and 2ml honey,15mg/kg dichlorvos and 3ml honey while the control group were given only food and water adlibitum for 21days. Serum bilirubin, Alanine amino transaminase (ALT), Aspartate amino transaminase (AST), Alkaline Phosphatase (ALP) Total Protein and albumin were estimated using Jendrassik-Grof method, Reitman, and Frankel method, Phenolphthalein Monophosphate method, Biuret method and Bromocresol Green (BCG) method respectively. Statistical Package for Social Sciences (SPSS) version 23 was used to analyze the data. Results and conclusion: There was significant difference (P<0.05) in AST (U/L) activity of 47.60±34.94, 115.80±13.27, 69.20±18.93, 82.60±31.68 and 103.6±17.80 in control, dichlorvos, dichlorvos and 1ml honey,  dichlorvos and 2ml honey and  dichlorvos and 3ml honey respectively. There were no significant difference (P>0.05) in ALT (U/L) and ALP (U/L) activities in all the treatments. Also no significant difference (P>0.05) was observed in Protein (g/l) and albumin (g/l) concentration as well as total bilirubin (Umol/L) and conjugated bilirubin (Umol/L) concentrations in all the treatments. The result of the study has shown that dichlorvos induced liver enzymes with increase in bilirubin and decrease proteins while treatment with honey reduced the induced enzymes.