Changes in Liver and renal function of Subjects infected with corona Virus 19 (COVID 19) on Zinc and Vitamin C in a Health care facility in Southern Nigeria

The COVID-19 outbreak by the new coronavirus strain was recognized as a pandemic by the World Health Organization (WHO). ). Vitamin C is a water soluble antioxidant vitamin. Zinc is crucial for many cellular processes, including the preservation of immune function and is an anti-inflammatory and antioxidant micronutrient. The aim of the study is to determine changes of some biochemical parameter in patient with COVID 19 administered with Vitamin C and Zinc treatments. Sixty three subjects who had symptoms and were admitted to the wards within the cottage hospital had their sample analysed for COVID-19, Total Protein, Albumin, alanine aminotransferase (ALT), aspartate aminotransferase(AST), alkaline phosphatase (Alk Phos) Total Bilirubin, Direct Bilirubin, Sodium, Potassium, Chloride, Bicarbonate, Urea and Creatinine using Biuret, Bromocresol green, Reitman and Frankel, Phenolphthalein Monophosphate, Jendrassik-Grof, ion selective electrode, Phosphoenol pyruvate carboxylase, Berthelots and Jaffe’s methods respectively. The data were analyzed using statistical package for social science (SPSS) version 25. There was no significant difference (P>0.05) in Total protein (g/L) and albumin(g/L) concentrations of 82.60+2.70 and 47.04+1.63 at baseline and 103.30+11.00 and 48.06+2.13 at post treatment. There was no significant difference (P>0.05) in AST (U/L) and ALT(U/L) activities of 2.77+0.14 and 2.14+0.13 at baseline and 6.71+3.23 and 9.10+3.89 at post treatment respectively. There was significant decrease (P<0.05) in ALKPHOS (U/L) between 159.97+8.98 at baseline and 77.88+10.14 at post treatment. There was no significant difference (P>0.05) in Total Bilirubin (Umol/L) between 5.90+0.60 at baseline and 6.90+1.60 at post treatment while the Direct bilirubin showed significant increase (P<0.05) from 0.90+0.12 at baseline to 1.55+0.30 at post treatment.There was no significant changes (P>0.5) in Sodium (Mmol/l), Potassium (Mmol/l) and Chloride (Mmol/l) concentrations of 147.69+3.16, 5.27+0.21,and 98.27+3.66 respectively at baseline compared with 144.93+3.82, 5.83+0.29 and 107.81+3.93 respectively Post Treatment. Bicarbonate (Mmol/l) and Creatinine (Umol/l) significantly increased from 16.17+1.81and 73.78+2.03 at baseline respectively to 38.40+2.17 and 151.42+15.98 at Post Treatment  while Urea (Mmo/l)  significantly reduced (P<0.05) from 21.00+3.97 at baseline to 10.62+2.71 at Post Treatment. The study showed that administration of Zinc and vitamin C to subjects with COVID 19 infection caused decrease alkaline phosphatase and urea levels with increase Direct Bilirubin, bicarbonate and creatinine in those patients.