Drug and substance use among university students is a problematic pattern of substance abuse leading to impairment in academic, social, or personal functioning, and requires professional intervention and support. This comprehensive review critically examined drug and substance use among university students. Identified as a problematic pattern leading to academic, social, or personal impairment, necessitating professional intervention, the study meticulously classified prevalent substances: alcohol, marijuana, prescription medications, nicotine, illicit drugs, inhalants, and club drugs. A thorough analysis of 31 cited references was conducted to explore the substances' prevalence, contributing factors, and consequences. The review reveals evolving social contexts, accessibility challenges, and shifting legal frameworks as influential factors in substance use trends. Identifying critical research gaps, the study emphasizes the imperative for inclusive studies on underrepresented demographics and the intersection of substance abuse with mental health. The research underscores the potential of technology in interventions and underscores the value of ongoing research for adapting strategies. Furthermore, the review highlights proactive measures, community partnerships, and inclusive policies as essential components in fostering a campus climate that prioritizes student welfare. The findings from this review should guide future research and interventions, providing a comprehensive understanding of substance use disorders among university students.
