Background: The human Monkey pox viral disease is an endemic zoonotic infection in some regions of Africa caused by monkey pox virus, with recent outbreaks occurring in several non-African countries
Aim: To determine the levels of C-reactive protein among Monkey pox patients attending Federal Medical Centre, Owerri, Imo State. Methodology: The study was conducted at the Federal Medical Center Imo State. Participants were individuals seeking medical attention for various conditions. 28 Samples were collected between May 1 and 31, 2022, their samples were test for Monkeypox via Polymerase Chain Reaction assay at the molecular laboratory in Abuja, 14 came back positive. Dermatologic tests were also conducted. Result: Predominantly aged 21-30, 57.1% male, and 42.9% students. Majority had symptoms for 1-10 days, identified as heterosexual, and unavailable pregnancy status. CRP concentrations were notably high. Acyclovir, antibiotics, and a combination of vitamins, anti-histamines, and zinc were common medications. Hospitalization in 85.7% cases, mostly lasting 1-10 days, with a positive treatment outcome for the majority, complications were observed in 21.4% of cases. Contact cases primarily occurred in the police cell and Corper’s lodge. Conclusion: This study shows that the concentration of CRP suggested inflammatory response, therefore the reason for quick recovery within 1-10 days.